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Oncogenic point mutations in the Myb DNA-binding domain alter the DNA-binding properties of Myb at a physiological target gene

The oncoprotein v-Myb of avian myeloblastosis virus (AMV) transforms myelomonocytic cells by deregulating specific target genes. Previous work has shown that the oncogenic potential of v-Myb was activated by truncation of N- and C-terminal sequences of c-Myb and was further increased by amino acid s...

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Dettagli Bibliografici
Autori principali: Ivanova, Olga, Braas, Daniel, Klempnauer, Karl-Heinz
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175353/
https://ncbi.nlm.nih.gov/pubmed/17959653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm675
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