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Deficiency of RecA-dependent RecFOR and RecBCD pathways causes increased instability of the (GAA·TTC)(n) sequence when GAA is the lagging strand template
The most common mutation in Friedreich ataxia is an expanded (GAA·TTC)(n) sequence, which is highly unstable in human somatic cells and in the germline. The mechanisms responsible for this genetic instability are poorly understood. We previously showed that cloned (GAA·TTC)(n) sequences replicated i...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2175318/ https://ncbi.nlm.nih.gov/pubmed/17932052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm810 |
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