Loading...

Tracking Col1a1 RNA in Osteogenesis Imperfecta: Splice-Defective Transcripts Initiate Transport from the Gene but Are Retained within the Sc35 Domain

This study illuminates the intra-nuclear fate of COL1A1 RNA in osteogenesis imperfecta (OI) Type I. Patient fibroblasts were shown to carry a heterozygous defect in splicing of intron 26, blocking mRNA export. Both the normal and mutant allele associated with a nuclear RNA track, a localized accumul...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Johnson, Carol, Primorac, Dragan, McKinstry, Monique, McNeil, John, Rowe, David, Lawrence, Jeanne Bentley
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175183/
https://ncbi.nlm.nih.gov/pubmed/10931857
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!