The Cysteine-Rich Domain of Human Adam 12 Supports Cell Adhesion through Syndecans and Triggers Signaling Events That Lead to β1 Integrin–Dependent Cell Spreading

The ADAMs (a disintegrin and metalloprotease) family of proteins is involved in a variety of cellular interactions, including cell adhesion and ecto- domain shedding. Here we show that ADAM 12 binds to cell surface syndecans. Three forms of recombinant ADAM 12 were used in these experiments: the cys...

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Main Authors: Iba, Kousuke, Albrechtsen, Reidar, Gilpin, Brent, Fröhlich, Camilla, Loechel, Frosty, Zolkiewska, Anna, Ishiguro, Kazuhiro, Kojima, Tetsuhito, Liu, Wei, Langford, J. Kevin, Sanderson, Ralph D., Brakebusch, Cord, Fässler, Reinhard, Wewer, Ulla M.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2000
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174829/
https://ncbi.nlm.nih.gov/pubmed/10831617
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