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Exact p-value calculation for heterotypic clusters of regulatory motifs and its application in computational annotation of cis-regulatory modules

BACKGROUND: cis-Regulatory modules (CRMs) of eukaryotic genes often contain multiple binding sites for transcription factors. The phenomenon that binding sites form clusters in CRMs is exploited in many algorithms to locate CRMs in a genome. This gives rise to the problem of calculating the statisti...

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Bibliografiske detaljer
Main Authors: Boeva, Valentina, Clément, Julien, Régnier, Mireille, Roytberg, Mikhail A, Makeev, Vsevolod J
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174486/
https://ncbi.nlm.nih.gov/pubmed/17927813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-7188-2-13
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