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Exact p-value calculation for heterotypic clusters of regulatory motifs and its application in computational annotation of cis-regulatory modules

BACKGROUND: cis-Regulatory modules (CRMs) of eukaryotic genes often contain multiple binding sites for transcription factors. The phenomenon that binding sites form clusters in CRMs is exploited in many algorithms to locate CRMs in a genome. This gives rise to the problem of calculating the statisti...

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Bibliographic Details
Main Authors: Boeva, Valentina, Clément, Julien, Régnier, Mireille, Roytberg, Mikhail A, Makeev, Vsevolod J
Format: Artigo
Language:Inglês
Published: BioMed Central 2007
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174486/
https://ncbi.nlm.nih.gov/pubmed/17927813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-7188-2-13
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