Effect of vitamin A supplementation on rhodopsin mutants threonine-17 → methionine and proline-347 → serine in transgenic mice and in cell cultures

A therapeutic effect of vitamin A supplementation on the course of photoreceptor degeneration, previously reported for patients with retinitis pigmentosa, was tested in two transgenic mouse models of this disease, each carrying a dominant rhodopsin mutation. The threonine-17 → methionine (T17M) muta...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Li, Tiansen, Sandberg, Michael A., Pawlyk, Basil S., Rosner, Bernard, Hayes, K. C., Dryja, Thaddeus P., Berson, Eliot L.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21743/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9751768/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.20.11933
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