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Analysis of Dynactin Subcomplexes Reveals a Novel Actin-Related Protein Associated with the Arp1 Minifilament Pointed End

The multisubunit protein, dynactin, is a critical component of the cytoplasmic dynein motor machinery. Dynactin contains two distinct structural domains: a projecting sidearm that interacts with dynein and an actin-like minifilament backbone that is thought to bind cargo. Here, we use biochemical, u...

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Detalhes bibliográficos
Main Authors: Eckley, D. Mark, Gill, Steven R., Melkonian, Karin A., Bingham, James B., Goodson, Holly V., Heuser, John E., Schroer, Trina A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 1999
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174220/
https://ncbi.nlm.nih.gov/pubmed/10525537
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