Strand asymmetry of CpG transitions as indicator of G(1) phase-dependent origin of multiple tumorigenic p53 mutations in stem cells
In dividing cells, expression of mutations is DNA strand symmetric. Of all mutations originating de novo in nondividing cells, only those in the transcribed (noncoding) strand are immediately expressed in mRNA and protein. In contrast, any new mutation in the nontranscribed (coding) strand remains u...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21742/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9751767/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.20.11927 |
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