Distribution and specificity of mutations induced by neocarzinostatin in the lacI gene of Escherichia coli.
Although neocarzinostatin (NCS) attacks DNA almost exclusively at adenine and thymine residues in vitro, exposure of Escherichia coli to this antitumor drug resulted in a high frequency of mutations at guanine:cytosine base pairs in the lacI gene. Thus, NCS-induced base substitution mutations do not...
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| Udgivet i: | J Bacteriol |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology (ASM)
1983
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC217383/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6217195/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.153.1.379-383.1983 |
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