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Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethality
Tropomodulin1 (Tmod1) caps thin filament pointed ends in striated muscle, where it controls filament lengths by regulating actin dynamics. Here, we investigated myofibril assembly and heart development in a Tmod1 knockout mouse. In the absence of Tmod1, embryonic development appeared normal up to em...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2003
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2173615/ https://ncbi.nlm.nih.gov/pubmed/14657235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200308164 |
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