FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B–enhanced cell survival through maintenance of mitochondrial integrity

Survival signals elicited by cytokines include the activation of phosphatidylinositol 3-kinase (PI3K), which in turn promotes the activation of protein kinase B (PKB). Recently, PKB has been demonstrated to phosphorylate and inactivate forkhead transcription factor FKHR-L1, a potent inducer of apopt...

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Main Authors: Dijkers, Pascale F., Birkenkamp, Kim U., Lam, Eric W.-F., Thomas, N. Shaun B., Lammers, Jan-Willem J., Koenderman, Leo, Coffer, Paul J.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2002
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173339/
https://ncbi.nlm.nih.gov/pubmed/11815629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200108084
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