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Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases
We show here the transient activation of the small GTPase Rac, followed by a rise in reactive oxygen species (ROS), as necessary early steps in a signal transduction cascade that lead to NFκB activation and collagenase-1 (CL-1)/matrix metalloproteinase-1 production after integrin-mediated cell shape...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Rockefeller University Press
2002
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2173123/ https://ncbi.nlm.nih.gov/pubmed/12119354 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200111028 |
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