Mossy fiber Zn(2+) spillover modulates heterosynaptic N-methyl-d-aspartate receptor activity in hippocampal CA3 circuits

Although Zn(2+) is contained in large amounts in the synaptic terminals of hippocampal mossy fibers (MFs), its physiological role in synaptic transmission is poorly understood. By using the newly developed high-sensitivity Zn(2+) indicator ZnAF-2, the spatiotemporal dynamics of Zn(2+) was monitored...

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Main Authors: Ueno, Sayaka, Tsukamoto, Masako, Hirano, Tomoya, Kikuchi, Kazuya, Yamada, Maki K., Nishiyama, Nobuyoshi, Nagano, Tetsuo, Matsuki, Norio, Ikegaya, Yuji
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2002
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173116/
https://ncbi.nlm.nih.gov/pubmed/12119362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200204066
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