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hNuf2 inhibition blocks stable kinetochore–microtubule attachment and induces mitotic cell death in HeLa cells

Identification of proteins that couple kinetochores to spindle microtubules is critical for understanding how accurate chromosome segregation is achieved in mitosis. Here we show that the protein hNuf2 specifically functions at kinetochores for stable microtubule attachment in HeLa cells. When hNuf2...

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Bibliografiske detaljer
Main Authors: DeLuca, Jennifer G., Moree, Ben, Hickey, Jennifer M., Kilmartin, John V., Salmon, E.D.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2002
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173110/
https://ncbi.nlm.nih.gov/pubmed/12438418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200208159
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