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Mutant DMPK 3′-UTR transcripts disrupt C2C12 myogenic differentiation by compromising MyoD

Myotonic dystrophy (DM) is caused by two similar noncoding repeat expansion mutations (DM1 and DM2). It is thought that both mutations produce pathogenic RNA molecules that accumulate in nuclear foci. The DM1 mutation is a CTG expansion in the 3′ untranslated region (3′-UTR) of dystrophia myotonica...

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Detalhes bibliográficos
Main Authors: Amack, Jeffrey D., Reagan, Shannon R., Mahadevan, Mani S.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173077/
https://ncbi.nlm.nih.gov/pubmed/12427866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200206020
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