Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis

During puberty, mouse mammary epithelial ducts invade the stromal mammary fat pad in a wave of branching morphogenesis to form a complex ductal tree. Using pharmacologic and genetic approaches, we find that mammary gland branching morphogenesis requires transient matrix metalloproteinase (MMP) activ...

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Detalhes bibliográficos
Main Authors: Wiseman, Bryony S., Sternlicht, Mark D., Lund, Leif R., Alexander, Caroline M., Mott, Joni, Bissell, Mina J., Soloway, Paul, Itohara, Shigeyoshi, Werb, Zena
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172848/
https://ncbi.nlm.nih.gov/pubmed/12975354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200302090
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