Dynamic phosphoregulation of the cortical actin cytoskeleton and endocytic machinery revealed by real-time chemical genetic analysis

We used chemical genetics to control the activity of budding yeast Prk1p, which is a protein kinase that is related to mammalian GAK and AAK1, and which targets several actin regulatory proteins implicated in endocytosis. In vivo Prk1p inhibition blocked pheromone receptor endocytosis, and caused co...

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Autors principals: Sekiya-Kawasaki, Mariko, Groen, Aaron Chris, Cope, M. Jamie T.V., Kaksonen, Marko, Watson, Hadiya A., Zhang, Chao, Shokat, Kevan M., Wendland, Beverly, McDonald, Kent L., McCaffery, J. Michael, Drubin, David G.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2003
Matèries:
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172809/
https://ncbi.nlm.nih.gov/pubmed/12952930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200305077
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