Direct observation of microtubule dynamics at kinetochores in Xenopus extract spindles: implications for spindle mechanics

Microtubule plus ends dynamically attach to kinetochores on mitotic chromosomes. We directly imaged this dynamic interface using high resolution fluorescent speckle microscopy and direct labeling of kinetochores in Xenopus extract spindles. During metaphase, kinetochores were stationary and under te...

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Autors principals: Maddox, Paul, Straight, Aaron, Coughlin, Peg, Mitchison, Timothy J., Salmon, Edward D.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2003
Matèries:
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172681/
https://ncbi.nlm.nih.gov/pubmed/12900391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200301088
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