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Anthrax toxin triggers endocytosis of its receptor via a lipid raft–mediated clathrin-dependent process

The protective antigen (PA) of the anthrax toxin binds to a cell surface receptor and thereby allows lethal factor (LF) to be taken up and exert its toxic effect in the cytoplasm. Here, we report that clustering of the anthrax toxin receptor (ATR) with heptameric PA or with an antibody sandwich caus...

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Detalhes bibliográficos
Main Authors: Abrami, Laurence, Liu, Shihui, Cosson, Pierre, Leppla, Stephen H., van der Goot, F. Gisou
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172673/
https://ncbi.nlm.nih.gov/pubmed/12551953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200211018
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