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Selective apoptosis of pluripotent mouse and human stem cells by novel ceramide analogues prevents teratoma formation and enriches for neural precursors in ES cell–derived neural transplants

The formation of stem cell–derived tumors (teratomas) is observed when engrafting undifferentiated embryonic stem (ES) cells, embryoid body–derived cells (EBCs), or mammalian embryos and is a significant obstacle to stem cell therapy. We show that in tumors formed after engraftment of EBCs into mous...

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Détails bibliographiques
Auteurs principaux: Bieberich, Erhard, Silva, Jeane, Wang, Guanghu, Krishnamurthy, Kannan, Condie, Brian G.
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2004
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172580/
https://ncbi.nlm.nih.gov/pubmed/15545317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200405144
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