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The 4q subtelomere harboring the FSHD locus is specifically anchored with peripheral heterochromatin unlike most human telomeres

This paper investigates the nuclear localization of human telomeres and, specifically, the 4q35 subtelomere mutated in facioscapulohumeral dystrophy (FSHD). FSHD is a common muscular dystrophy that has been linked to contraction of D4Z4 tandem repeats, widely postulated to affect distant gene expres...

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Bibliographic Details
Main Authors: Tam, Rose, Smith, Kelly P., Lawrence, Jeanne B.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2004
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172553/
https://ncbi.nlm.nih.gov/pubmed/15504910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200403128
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