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Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors
The Ras-related GTPase Rap1 stimulates integrin-mediated adhesion and spreading in various mammalian cell types. Here, we demonstrate that Rap1 regulates cell spreading by localizing guanine nucleotide exchange factors (GEFs) that act via the Rho family GTPase Rac1. Rap1a activates Rac1 and requires...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2172522/ https://ncbi.nlm.nih.gov/pubmed/15479739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200404068 |
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