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Expression and crystallization of the complex of HLA-DR2 (DRA, DRB1*1501) and an immunodominant peptide of human myelin basic protein

HLA-DR2 is associated with susceptibility to multiple sclerosis (MS). A peptide from human myelin basic protein (MBP, residues 85–99) was previously found to bind to purified HLA-DR2 (DRA, DRB1*1501) and to be recognized by human MBP-specific T cell clones. Soluble HLA-DR2 was expressed in the bacul...

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Uloženo v:
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Gauthier, Laurent, Smith, Kathrine J., Pyrdol, Jason, Kalandadze, Avtandil, Strominger, Jack L., Wiley, Don C., Wucherpfennig, Kai W.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 1998
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21725/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9751750/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.20.11828
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