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Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts

We examined the role of regulatory myosin light chain (MLC) phosphorylation of myosin II in cell migration of fibroblasts. Myosin light chain kinase (MLCK) inhibition blocked MLC phosphorylation at the cell periphery, but not in the center. MLCK-inhibited cells did not assemble zyxin-containing adhe...

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Bibliografske podrobnosti
Main Authors: Totsukawa, Go, Wu, Yue, Sasaki, Yasuharu, Hartshorne, David J., Yamakita, Yoshihiko, Yamashiro, Shigeko, Matsumura, Fumio
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2004
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172229/
https://ncbi.nlm.nih.gov/pubmed/14757754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200306172
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