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Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts

We examined the role of regulatory myosin light chain (MLC) phosphorylation of myosin II in cell migration of fibroblasts. Myosin light chain kinase (MLCK) inhibition blocked MLC phosphorylation at the cell periphery, but not in the center. MLCK-inhibited cells did not assemble zyxin-containing adhe...

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Detalhes bibliográficos
Main Authors: Totsukawa, Go, Wu, Yue, Sasaki, Yasuharu, Hartshorne, David J., Yamakita, Yoshihiko, Yamashiro, Shigeko, Matsumura, Fumio
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172229/
https://ncbi.nlm.nih.gov/pubmed/14757754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200306172
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