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Laminin–sulfatide binding initiates basement membrane assembly and enables receptor signaling in Schwann cells and fibroblasts

Endoneurial laminins (Lms), β1-integrins, and dystroglycan (DG) are important for Schwann cell (SC) ensheathment and myelination of axons. We now show that SC expression of galactosyl-sulfatide, a Lm-binding glycolipid, precedes that of Lms in developing nerves. This glycolipid anchors Lm-1 and -2 t...

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Main Authors: Li, Shaohua, Liquari, Patricia, McKee, Karen K., Harrison, David, Patel, Raj, Lee, Sean, Yurchenco, Peter D.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2005
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171891/
https://ncbi.nlm.nih.gov/pubmed/15824137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200501098
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