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Botulinum neurotoxin C initiates two different programs for neurite degeneration and neuronal apoptosis

Clostridial neurotoxins are bacterial endopeptidases that cleave the major SNARE proteins in peripheral motorneurons. Here, we show that disruption of synaptic architecture by botulinum neurotoxin C1 (BoNT/C) in central nervous system neurons activates distinct neurodegenerative programs in the axo-...

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Detalhes bibliográficos
Main Authors: Berliocchi, Laura, Fava, Eugenio, Leist, Marcel, Horvat, Volker, Dinsdale, David, Read, David, Nicotera, Pierluigi
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171755/
https://ncbi.nlm.nih.gov/pubmed/15716378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200406126
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