Coordinate control of axon defasciculation and myelination by laminin-2 and -8

Schwann cells form basal laminae (BLs) containing laminin-2 (Ln-2; heterotrimer α2β1γ1) and Ln-8 (α4β1γ1). Loss of Ln-2 in humans and mice carrying α2-chain mutations prevents developing Schwann cells from fully defasciculating axons, resulting in partial amyelination. The principal pathogenic mecha...

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Autors principals: Yang, Dongren, Bierman, Jesse, Tarumi, Yukie S., Zhong, Yong-Ping, Rangwala, Reshma, Proctor, Thomas M., Miyagoe-Suzuki, Yuko, Takeda, Shin'ichi, Miner, Jeffrey H., Sherman, Larry S., Gold, Bruce G., Patton, Bruce L.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2005
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171752/
https://ncbi.nlm.nih.gov/pubmed/15699217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200411158
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