Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis

Focal adhesion kinase (FAK) is a critical mediator of signal transduction by integrins and growth factor receptors in a variety of cells including endothelial cells (ECs). Here, we describe EC-specific knockout of FAK using a Cre-loxP approach. In contrast to the total FAK knockout, deletion of FAK...

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Main Authors: Shen, Tang-Long, Park, Ann Y.-J., Alcaraz, Ana, Peng, Xu, Jang, Ihnkyung, Koni, Pandelakis, Flavell, Richard A., Gu, Hua, Guan, Jun-Lin
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2005
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171636/
https://ncbi.nlm.nih.gov/pubmed/15967814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200411155
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