Support for the immortal strand hypothesis: neural stem cells partition DNA asymmetrically in vitro

The immortal strand hypothesis proposes that asymmetrically dividing stem cells (SCs) selectively segregate chromosomes that bear the oldest DNA templates. We investigated cosegregation in neural stem cells (NSCs). After exposure to the thymidine analogue 5-bromo-2-deoxyuridine (BrdU), which labels...

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Detalhes bibliográficos
Main Authors: Karpowicz, Phillip, Morshead, Cindi, Kam, Angela, Jervis, Eric, Ramunas, John, Cheng, Vincent, van der Kooy, Derek
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171352/
https://ncbi.nlm.nih.gov/pubmed/16115957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200502073
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