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Osmotic stress blocks NF-κB-dependent inflammatory responses by inhibiting ubiquitination of IκB

The inhibitory effects of hypertonic conditions on immune responses have been described in clinical studies; however, the molecular mechanism underlying this phenomenon has yet to be defined. Here we investigate osmotic stress-mediated modification of the NF-κB pathway, a central signaling pathway i...

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Main Authors: HuangFu, Wei-Chun, Matsumoto, Kunihiro, Ninomiya-Tsuji, Jun
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2170878/
https://ncbi.nlm.nih.gov/pubmed/17997988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.11.002
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