Interferon-γ induced increases in intracellular calcium in T lymphocytes from patients with multiple sclerosis precede clinical exacerbations and detection of active lesions on MRI

BACKGROUND—Interferon (IFN)-γ exerts a multiplicity of actions potentially relevant for the pathogenesis of multiple sclerosis, including the expression of a transplasmalemma calcium (Ca(2+)) influx leading to an intracellular Ca(2+) ([Ca(2+)](i)) increase able to lower T lymphocyte threshold of exc...

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Main Authors: Martino, G, Filippi, M, Martinelli, V, Brambilla, E, Gobbi, C, Comi, G, Grimaldi, L
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 1997
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169707/
https://ncbi.nlm.nih.gov/pubmed/9328251
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