Identification of Candidate Angiogenic Inhibitors Processed by Matrix Metalloproteinase 2 (MMP-2) in Cell-Based Proteomic Screens: Disruption of Vascular Endothelial Growth Factor (VEGF)/Heparin Affin Regulatory Peptide (Pleiotrophin) and VEGF/Connective Tissue Growth Factor Angiogenic Inhibitory Complexes by MMP-2 Proteolysis

Matrix metalloproteinases (MMPs) exert both pro- and antiangiogenic functions by the release of cytokines or proteolytically generated angiogenic inhibitors from extracellular matrix and basement membrane remodeling. In the Mmp2(−/−) mouse neovascularization is greatly reduced, but the mechanistic a...

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Detalhes bibliográficos
Main Authors: Dean, Richard A., Butler, Georgina S., Hamma-Kourbali, Yamina, Delbé, Jean, Brigstock, David R., Courty, José, Overall, Christopher M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169415/
https://ncbi.nlm.nih.gov/pubmed/17908800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00821-07
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