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Human Papillomavirus E6 Proteins Mediate Resistance to Interferon-Induced Growth Arrest through Inhibition of p53 Acetylation

The high-risk human papillomavirus (HPV) E6 and E7 proteins act cooperatively to mediate multiple activities in viral pathogenesis. For instance, E7 acts to increase p53 levels while E6 accelerates its rate of turnover through the binding of the cellular ubiquitin ligase E6AP. Interferons are import...

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Detalhes bibliográficos
Main Authors: Hebner, Christy, Beglin, Melanie, Laimins, Laimonis A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169108/
https://ncbi.nlm.nih.gov/pubmed/17898049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00987-07
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