Human Rhinovirus Type 14 Gain-of-Function Mutants for oriI Utilization Define Residues of 3C(D) and 3Dpol That Contribute to Assembly and Stability of the Picornavirus VPg Uridylylation Complex

VPg linkage to the 5′ ends of picornavirus RNAs requires production of VPg-pUpU. VPg-pUpU is templated by an RNA stem-loop (the cre or oriI) found at different locations in picornavirus genomes. At least one adaptive mutation is required for human rhinovirus type 14 (HRV-14) to use poliovirus type 3...

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Detalhes bibliográficos
Main Authors: Shen, Miaoqing, Wang, Qixin, Yang, Yan, Pathak, Harsh B., Arnold, Jamie J., Castro, Christian, Lemon, Stanley M., Cameron, Craig E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169002/
https://ncbi.nlm.nih.gov/pubmed/17855535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00972-07
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