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Proteolysis of the Ebola Virus Glycoproteins Enhances Virus Binding and Infectivity

Cellular cathepsins are required for Ebola virus infection and are believed to proteolytically process the Ebola virus glycoprotein (GP) during entry. However, the significance of cathepsin cleavage during infection remains unclear. Here we demonstrate a role for cathepsin L (CatL) cleavage of Ebola...

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Détails bibliographiques
Auteurs principaux: Kaletsky, Rachel L., Simmons, Graham, Bates, Paul
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2007
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168880/
https://ncbi.nlm.nih.gov/pubmed/17928356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01170-07
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