DDX3 DEAD-Box RNA Helicase Is Required for Hepatitis C Virus RNA Replication

DDX3, a DEAD-box RNA helicase, binds to the hepatitis C virus (HCV) core protein. However, the role(s) of DDX3 in HCV replication is still not understood. Here we demonstrate that the accumulation of both genome-length HCV RNA (HCV-O, genotype 1b) and its replicon RNA were significantly suppressed i...

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Bibliographic Details
Main Authors: Ariumi, Yasuo, Kuroki, Misao, Abe, Ken-ichi, Dansako, Hiromichi, Ikeda, Masanori, Wakita, Takaji, Kato, Nobuyuki
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2007
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168844/
https://ncbi.nlm.nih.gov/pubmed/17855521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01517-07
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