Phosphopantetheine Adenylyltransferase from Escherichia coli: Investigation of the Kinetic Mechanism and Role in Regulation of Coenzyme A Biosynthesis

Phosphopantetheine adenylyltransferase (PPAT) from Escherichia coli is an essential hexameric enzyme that catalyzes the penultimate step in coenzyme A (CoA) biosynthesis and is a target for antibacterial drug discovery. The enzyme utilizes Mg-ATP and phosphopantetheine (PhP) to generate dephospho-Co...

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Bibliographische Detailangaben
Hauptverfasser: Miller, J. Richard, Ohren, Jeffrey, Sarver, Ronald W., Mueller, W. Thomas, Dreu, Piet de, Case, Heather, Thanabal, Venkataraman
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2007
Schlagworte:
Physiology and Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168673/
https://ncbi.nlm.nih.gov/pubmed/17873050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00732-07
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