Comparative Genomic Hybridization Detects Secondary Chromosomal Deletions in Escherichia coli K-12 MG1655 Mutants and Highlights Instability in the flhDC Region

The use of whole-genome microarrays for monitoring mutagenized or otherwise engineered genetic derivatives is a potentially powerful tool for checking genomic integrity. Using comparative genomic hybridization of a number of unrelated, directed deletion mutants in Escherichia coli K-12 MG1655, we id...

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Autori principali: Hobman, Jon L., Patel, Mala D., Hidalgo-Arroyo, G. Aida, Cariss, S. James L., Avison, Matthew B., Penn, Charles W., Constantinidou, Chrystala
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2007
Soggetti:
Genomics and Proteomics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168620/
https://ncbi.nlm.nih.gov/pubmed/17921306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00977-07
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