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The p38 Mitogen-Activated Protein Kinase Signaling Pathway Is Coupled to Toll-Like Receptor 5 To Mediate Gene Regulation in Response to Pseudomonas aeruginosa Infection in Human Airway Epithelial Cells

In this study, we show that stimulation of human airway epithelial cells (HAECs) by Pseudomonas aeruginosa strain PAO1 induces time- and dose-dependent activation of p38 mitogen-activated protein kinase (MAPK). Activated p38 MAPK stayed in the cytoplasm instead of translocating to the nucleus, as sh...

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Detalhes bibliográficos
Main Authors: Zhang, Zhe, Reenstra, William, Weiner, Daniel J., Louboutin, Jean-Pierre, Wilson, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168327/
https://ncbi.nlm.nih.gov/pubmed/17908812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00678-07
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