Antileishmanial Structure-Activity Relationships of Synthetic Phospholipids: In Vitro and In Vivo Activities of Selected Derivatives

Antileishmanial activities of 91 synthetic phospholipids against Leishmania donovani were evaluated in vitro and cytotoxicity assessed against two mammalian cell lines. Promising compounds were tested further in vivo. In vitro structure-activity relationships showed a positive contribution of head g...

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Bibliographic Details
Main Authors: Seifert, Karin, Lemke, Andreas, Croft, Simon L., Kayser, Oliver
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2007
Subjects:
Susceptibility
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2167978/
https://ncbi.nlm.nih.gov/pubmed/17908944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00465-07
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