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Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia

Patients with X-linked hypophosphatemia (XLH) and the hyp-mouse, a model of XLH characterized by a deletion in the Phex gene, manifest hypophosphatemia, renal phosphate wasting, and rickets/osteomalacia. Cloning of the PHEX/Phex gene and mutations in affected patients and hyp-mice established that a...

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Библиографические подробности
Главные авторы: Yuan, Baozhi, Takaiwa, Masanori, Clemens, Thomas L., Feng, Jian Q., Kumar, Rajiv, Rowe, Peter S., Xie, Yixia, Drezner, Marc K.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2008
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2157563/
https://ncbi.nlm.nih.gov/pubmed/18172553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32702
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