Drosophila Apc2 Is a Cytoskeletally-Associated Protein That Regulates Wingless Signaling in the Embryonic Epidermis

The tumor suppressor adenomatous polyposis coli (APC) negatively regulates Wingless (Wg)/Wnt signal transduction by helping target the Wnt effector β-catenin or its Drosophila homologue Armadillo (Arm) for destruction. In cultured mammalian cells, APC localizes to the cell cortex near the ends of mi...

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Bibliografiske detaljer
Main Authors: McCartney, Brooke M., Dierick, Herman A., Kirkpatrick, Catherine, Moline, Melissa M., Baas, Annette, Peifer, Mark, Bejsovec, Amy
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 1999
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2156123/
https://ncbi.nlm.nih.gov/pubmed/10491393
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