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Apoptotic Activities of Wild-Type and Alzheimer's Disease-Related Mutant Presenilins in Drosophila melanogaster

Mutant human presenilins cause early-onset familial Alzheimer's disease and render cells susceptible to apoptosis in cultured cell models. We show that loss of presenilin function in Drosophila melanogaster increases levels of apoptosis in developing tissues. Moreover, overexpression of preseni...

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Sonraí Bibleagrafaíochta
Main Authors: Ye, Yihong, Fortini, Mark E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Rockefeller University Press 1999
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2156122/
https://ncbi.nlm.nih.gov/pubmed/10491396
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