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Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells
The reduction of iron is an essential step in the transferrin (Tf) cycle, which is the dominant pathway for iron uptake by red blood cell (RBC) precursors. A deficiency in RBC iron acquisition leads to a hypochromic, microcytic anemia. Using a positional cloning strategy, we have identified a gene,...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2156108/ https://ncbi.nlm.nih.gov/pubmed/16227996 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng1658 |
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