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Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice

BH3-only proteins couple diverse stress signals to the evolutionarily conserved mitochondrial apoptosis pathway. Previously, we reported that the activation of the BH3-only protein p53-up-regulated mediator of apoptosis (Puma) was necessary and sufficient for endoplasmic reticulum (ER) stress- and p...

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Detalhes bibliográficos
Main Authors: Kieran, Dairín, Woods, Ina, Villunger, Andreas, Strasser, Andreas, Prehn, Jochen H. M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2154478/
https://ncbi.nlm.nih.gov/pubmed/18077368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707906105
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