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Functional and nonfunctional mutations distinguished by random recombination of homologous genes
We describe a convenient method for distinguishing functional from nonfunctional or deleterious mutations in homologous genes. High fidelity in vitro gene recombination (“DNA shuffling”) coupled with sequence analysis of a small sampling of the shuffled library exhibiting the evolved behavior allows...
Gorde:
| Egile Nagusiak: | , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
The National Academy of Sciences of the USA
1997
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC21544/ https://ncbi.nlm.nih.gov/pubmed/9223302 |
| Etiketak: |
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