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Importance of Hydration and Dynamics on the Selectivity of the KcsA and NaK Channels
Fundamental concepts governing ion selectivity in narrow pores are reviewed and the microscopic factors responsible for the lack of selectivity of the NaK channel, which is structurally similar to the K(+)-selective KcsA channel, are elucidated on the basis of all-atom molecular dynamics free energy...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2154357/ https://ncbi.nlm.nih.gov/pubmed/17227917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200609633 |
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