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Importance of Hydration and Dynamics on the Selectivity of the KcsA and NaK Channels

Fundamental concepts governing ion selectivity in narrow pores are reviewed and the microscopic factors responsible for the lack of selectivity of the NaK channel, which is structurally similar to the K(+)-selective KcsA channel, are elucidated on the basis of all-atom molecular dynamics free energy...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Noskov, Sergei Yu., Roux, Benoît
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2154357/
https://ncbi.nlm.nih.gov/pubmed/17227917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200609633
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