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Importance of Hydration and Dynamics on the Selectivity of the KcsA and NaK Channels

Fundamental concepts governing ion selectivity in narrow pores are reviewed and the microscopic factors responsible for the lack of selectivity of the NaK channel, which is structurally similar to the K(+)-selective KcsA channel, are elucidated on the basis of all-atom molecular dynamics free energy...

詳細記述

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書誌詳細
主要な著者: Noskov, Sergei Yu., Roux, Benoît
フォーマット: Artigo
言語:Inglês
出版事項: The Rockefeller University Press 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2154357/
https://ncbi.nlm.nih.gov/pubmed/17227917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200609633
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