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Accessibility of Targeted DHPR Sites to Streptavidin and Functional Effects of Binding on EC Coupling

In skeletal muscle, the dihydropyridine receptor (DHPR) in the plasma membrane (PM) serves as a Ca(2+) channel and as the voltage sensor for excitation–contraction (EC coupling), triggering Ca(2+) release via the type 1 ryanodine receptor (RyR1) in the sarcoplasmic reticulum (SR) membrane. In additi...

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Autores principales: Lorenzon, Nancy M., Beam, Kurt G.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151652/
https://ncbi.nlm.nih.gov/pubmed/17893191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200609730
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