Phosphoinositide 3-Kinase Binds to TRPV1 and Mediates NGF-stimulated TRPV1 Trafficking to the Plasma Membrane

Sensitization of the pain-transducing ion channel TRPV1 underlies thermal hyperalgesia by proalgesic agents such as nerve growth factor (NGF). The currently accepted model is that the NGF-mediated increase in TRPV1 function during hyperalgesia utilizes activation of phospholipase C (PLC) to cleave P...

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Detaylı Bibliyografya
Asıl Yazarlar: Stein, Alexander T., Ufret-Vincenty, Carmen A., Hua, Li, Santana, Luis F., Gordon, Sharona E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2006
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151588/
https://ncbi.nlm.nih.gov/pubmed/17074976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200609576
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