In vitro circumvention of cisplatin resistance by the novel sterically hindered platinum complex AMD473.

A novel sterically hindered platinum complex, AMD473 [cis-aminedichloro(2-methylpyridine) platinum (II)], has been selected for phase I clinical trials due to commence in 1997. AMD473 was rationally designed to react preferentially with nucleic acids over sulphur ligands such as glutathione. This re...

Full description

Saved in:
Bibliographic Details
Main Authors: Holford, J., Sharp, S. Y., Murrer, B. A., Abrams, M., Kelland, L. R.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1998
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151285/
https://ncbi.nlm.nih.gov/pubmed/9472630
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items